PREPARATION AND CHARACTERIZATION OF A CipHCl-PLA/PBC/CS COMPOSITE FIBER MEMBRANE FOR ANTIBACTERIAL WOUND DRESSING
نویسندگان
چکیده
In this paper, a polylactic acid (PLA)/polybutylene carbonate (PBC)/chitosan (CS) composite membrane with different mass fractions of ciprofloxacin hydrochloride (CipHCl) drug was prepared through the electrostatic spinning technology. The morphology and chemical structure resultant CipHCl-PLA/PBC/CS fiber membranes were characterized scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) X-ray diffraction (XRD). A drug-release test, bacteriostatic test cytotoxicity performed to determine properties, properties cytotoxicity, respectively. Results show that have good biocompatibility. When CipHCl content is 20 w/%, average diameter 374 nm. After 192 h, rate containing w/% reaches 88.2 %. antibacterial activity much higher than PLA/PBC membrane. Besides, against E. coli slightly S. aureus.
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ژورنال
عنوان ژورنال: Materiali in Tehnologije
سال: 2022
ISSN: ['1580-2949', '1580-3414']
DOI: https://doi.org/10.17222/mit.2022.444